Do Large Clinical Trials Adequately Consider Individual Patient Physiology? Debating The RELIEF Study

By Michael Keane, BMBS, FANZCA and Shashikanth Manikappa, MD, DNB, FANZCA
February 21, 2019

Patient safety requires a well-informed debate about the rationale of large, randomized controlled trials (RCTs) and whether, by their very nature, they can adequately consider the unique physiology of every individual patient. 

New Born Lizzie Western-Inspired Boot Cognac Burnished LadiesNew BRUNELLO CUCINELLI Brown Leather Ankle Boots shoes Size 38.5 8.5 2320NEW CAMELBAK Rogue Hydration Pack 2.5L - Black Graphite Camelbak Botanex  Continue reading “Do Large Clinical Trials Adequately Consider Individual Patient Physiology? Debating The RELIEF Study”

WAKE-UP Time for Thrombolysis in Acute Stroke?

New Balance deportes femenino blue

By Martina McGrath, MD
October 30, 2018

MRI thrombolysis for stroke of unknown time of onset

New CELINE Black Leather Platform Wedge THIGH HIGH Boots 39 Phoebe Philo runwayNEW Christian Louboutin Cate Chain Flat Riding Copper Brown Boots 37 NIBNEW CLARKS Faralyn Dawn Black Suede Boots - UK size 7.5D

Prior studies have suggested a particular pattern may be seen on an MRI of the brain in the early hours following stroke onset; a visible ischemic lesion on diffusion-weighted imaging along with the lack of a hyperintense signal in the same area on fluid-attenuated inversion recovery (FLAIR). The benefit of aggressive stroke intervention in patients with the combination of unknown time of symptom onset and this particular signal mismatch on MRI brain scans is unknown. Continue reading “WAKE-UP Time for Thrombolysis in Acute Stroke?”

New Balance Fresh Foam Hierro Trail Running shoes, Women's Size 5B, Teal NEW

By Olivier Lucar
October 16, 2018

NEW Clarks Womens Leather LONG KNEE HIGH boots MINT AQUA GORETEX TANNew Cole Haan Women's Patent Black Wedge Pump shoes Sz 7.5New Columbia Mens Newton Ridge Cordovan, Squash Hiking Boots Size 10.5New COUTURE Evening shoes Pumps SIZE 7.5 - Black Beaded Made in NEWNEW Dansko Sheena Boots 36 Stone Nubuck shoes EU 36 Slouchy Wedge Bootie NIBNew Balance Fresh Foam Zante V4 Sneaker, Women's, Size 8.5, Storm bluee


By Connor Emdin
September 26, 2018

NEW DIADORA x HANON N9000 THE SATURDAY SPECIAL - RARE - US11NEW Dr Martens Ashfeld Dark Brown Mens Size 9 Pebbled Leather shoes NWOB 325188New Dsquared2 Men's Tennis shoes White Sneakers 551 Size 44 Vitello Sport SaleNEW ELIE TAHARI BLACK LEATHER FALLON BOOTIE WEDGE BOOTS SHOES SZ 40.5 US 10.5 Continue reading “Use of Guideline-Recommended Medical Therapy in Patients with Heart Failure”

Restrictive versus Liberal Fluid Therapy in Abdominal Surgery

By Connor Emdin
August 28, 2018

NEW FASHION MENS HIGH ANKLE BOOTS LACE UP OXFORDS WING TIP ZiPPERED DRESS SHOESNEW FERRICELLI MORRISON MENS LEATHER LACE UP CASUAL SHOES MADE IN BRAZILNew Franco Sarto Women's Carlano Riding Boot Small Heels Solid Black Size 6 1New Free People Women's Vintage Tan Leather Carrera Heel Boots Size 7 37 Continue reading “Restrictive versus Liberal Fluid Therapy in Abdominal Surgery”

Epinephrine in Out-Of-Hospital Cardiac Arrest: Increased Survival but at What Cost?

By Martina McGrath, MD
August 8, 2018

It is estimated that 1 in every 7.5 people in the US will die of sudden cardiac death.NEW BALANCE MAN FREE TIME CASUAL SNEAKER SHOES LEATHER CODE NM358WWW Survival following out-of-hospital cardiac arrest has increased in recent years, from 10.2% in 2006, to 12.4% in 2015.1 However, only 9% of those surviving to hospital discharge were classified as having good functional status. Therefore, significant long-term neurologic impairment is a common outcome of cardiac arrest. Continue reading “Epinephrine in Out-Of-Hospital Cardiac Arrest: Increased Survival but at What Cost?”

Cervical Cancer Screening Using HPV Testing Alone: Are We There Yet?

New Balance Men's Burn Mid Speed Lacrosse shoes

By Martina McGrath, MD
July 18, 2018

NEW FRYE WOMEN'S STONE LEATHER SHIRLEY PLATE RIDING BOOTS WOMAN'S SIZE 6New Giorgio Armani Men Taupe Brown Leather Fashion High Boots Size 7.5 1250New Grinders Renegade Hi Dark Brown Mens Cowboy Boots ALL SIZESNew Hi-Tec Womens Altitude Lite Waterproof Suede Athletic Hiking Boots Sz 6.5 New Balance Men's Fresh Foam 1450W Hiking shoes Chocolate Brown Team Away Grey


Dulaglutide in Type 2 Diabetes: Do GLP-1 agonists delay progression of diabetic nephropathy?

New Balance Mens MSVPSMH2 Fabric Low Top Lace Up Baseball shoes

By Connor Emdin
June 27, 2018

NEW IN BOX MENS AIR JORDAN 6 & 7 Retro golden Moments Pack 535357-935 SIZE 12NEW In Box Harley Davidson Mens Boots D93379 Keating Size 13 Medium WheatNew in Box Women's Tory Burch,Claire Ballet Flat Tumbled Leather-Bright Navy10.5New J. CREW Metropolitan Tan Suede Leather Ankle Boots Booties Size 7 New Balance Men's MW928BK2 Black Leather Walking shoes

Procalcitonin-Guided Antibiotic Therapy in Lower Respiratory Tract Infection: Is It Safe?

New Balance Minimus Tour NBG1007 shoes Athlétiques

By Martina McGrath, MD
June 5, 2018

NEW JEFFREY CAMPBELL STELLA GREY SUEDE SLOUCH BOOTS US 6NEW JORDAN RETRO 1 SIZE 8.5 NOT FOR RESALE 1 861428 106 1s RED No photos New Balance Mrl996ms Classic Sneaker Men's shoes Black 996

New Balance MX623LT3 Mens 623v3 Cross Training shoesD US- Choose SZ color.

NEW KEEN Women's Terradora Mid Waterproof hiking boot Stormy Weather Size 9.5

By Lea Borgi, MD
May 16, 2018

NEW KITON NAPOLI SHOES 100% LEATHER CROCODILE SIZE 10.5 US 43.5 EU KSH83New Ladies Autumn Slip on Mid Calf Boots Korean Style Letter Print Flats shoesNEW LL Bean Signature Wool Tall Duck Boot Out of Production Buffalo Plaid Sz 9 Continue reading “Does Menu Labeling Lead to Healthier Food Choices?”